Put your back against the wall, and try to take one out as quickly as possible. Here you'll get jumped by a Giant Spider, and a more dangerous Poison Spider.Here is a chest that has Fade Striders as well as a random item.Then try to take out the closest one as fast as possible, to keep things one on one as much as possible. So my approach was simply to run back the way I came fast as I could once one of them appeared. Its easy to get killed if one of them knocks you down, and then they both start to chew on you. Here you'll get attacked by two Giant Spiders.
In the meantime, here is a cocoon from which you can get a random item. Another one is a knockdown attack, after which the Spider will chew on you for a bit. One is a web which you'll break out from after a while. One holds a random item, and the other holds a Spirit Charm as well as a random item.
